2143061-82-7

2143061-82-7 structure

Name: AZD-5991 S-enantiomer
Chemical Name: AZD-5991 S-enantiomer
CAS Number: 2143061-82-7
Molecular Formula: C₃₅H₃₄ClN₅O₃S₂
Molecular Weight: 672.26
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2019-02-09 09:04:44
Modify Date: 2025-08-26 19:00:33
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.

Name	AZD-5991 S-enantiomer

Description	AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1:6.3 μM (IC50) Mcl-1:0.98 μM (Kd)
References	[1]. Tron AE, et al. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018 Dec 17;9(1):5341.

Molecular Formula	C₃₅H₃₄ClN₅O₃S₂
Molecular Weight	672.26