DC Chemicals Limited
China
Product Name: CCR2 antagonist 1
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Purity: 98.0%
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Contact: Tony Cao

1683534-96-4

1683534-96-4 structure

1683534-96-4 structure

Name: CCR2 antagonist 1
Chemical Name: CCR2 antagonist 1
CAS Number: 1683534-96-4
Molecular Formula: C₂₈H₃₂BrF₃N₂O
Molecular Weight: 549.47
Catalog: Signaling Pathways GPCR/G Protein CCR
Create Date: 2019-02-08 09:13:50
Modify Date: 2024-01-11 20:37:32
CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

Name	CCR2 antagonist 1

Description	CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Signaling Pathways >> Immunology/Inflammation >> CCR Research Areas >> Others
Target	CCR2:2.4 nM (Ki)
In Vitro	The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].
References	[1]. Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.

Molecular Formula	C₂₈H₃₂BrF₃N₂O
Molecular Weight	549.47