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854171-35-0

854171-35-0 structure
854171-35-0 structure
  • Name: Indirubin E804
  • Chemical Name: Indirubin Derivative E804
  • CAS Number: 854171-35-0
  • Molecular Formula: C20H19N3O4
  • Molecular Weight: 365.38
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK IGF-1R
  • Create Date: 2019-02-12 07:09:05
  • Modify Date: 2025-08-23 13:34:24
  • E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.

Name Indirubin Derivative E804
Description E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.
Related Catalog
Target

IC50: 0.65 μM (IGF1R)[1].

In Vitro Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM[1].
References

[1]. Cheng X, et al. Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. J Med Chem. 2017 Jun 22;60(12):4949-4962.

Molecular Formula C20H19N3O4
Molecular Weight 365.38
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