2172651-73-7

2172651-73-7 structure

Name: RMC-4550
Chemical Name: RMC-4550
CAS Number: 2172651-73-7
Molecular Formula: C₂₁H₂₆Cl₂N₄O₂
Molecular Weight: 437.36
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2019-02-18 21:05:04
Modify Date: 2024-01-13 11:29:21
RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.

Name	RMC-4550

Description	RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Cancer
Target	IC50:0.583 nM (SHP2)[1].
In Vitro	RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2[1].
References	[1]. Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 Sep;20(9):1064-1073.