603987-59-3
603987-59-3 structure
- Name: TY-51469
- Chemical Name: TY-51469
- CAS Number: 603987-59-3
- Molecular Formula: C20H15FN2O6S4
- Molecular Weight: 526.60
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2019-03-03 12:36:58
- Modify Date: 2024-02-02 15:38:58
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TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
| Name | TY-51469 |
|---|
| Description | TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.4 nM (Simian chymase), 0.7 nM (Human chymase)[1] |
| In Vivo | TY-51469 shows 100% stability in rat plasma at 40°C for as long as 1 hour[1]. TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice[2]. |
| Animal Admin | Rats[1] The 2-week intravenous repeated-dose toxicity study of TY-51469 was conducted in male Sprague-Dawley rats at daily doses of 0 (control), 20, and 60 mg/kg[1]. Mice[1] the chymase inhibitor TY-51469 was administered daily at a dose of 0.1 or 1.0 mg/kg/day for 21 days using an osmotic pump to male 8-week-old ICR mice. The osmotic pump released the drug solution continuously at a rate of 0.3 µL/h for 21 days[2]. |
| References |
| Molecular Formula | C20H15FN2O6S4 |
|---|---|
| Molecular Weight | 526.60 |