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1252362-53-0

1252362-53-0 structure
1252362-53-0 structure
  • Name: LRE1
  • Chemical Name: LRE1
  • CAS Number: 1252362-53-0
  • Molecular Formula: C12H13ClN4S
  • Molecular Weight: 280.78
  • Catalog: Signaling Pathways GPCR/G Protein Adenylate Cyclase
  • Create Date: 2019-03-01 19:38:23
  • Modify Date: 2024-01-06 21:18:09
  • LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.

Name LRE1
Description LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.
Related Catalog
Target

Adenylyl cyclase[1]

In Vitro LRE1 binds to the bicarbonate activator binding site and inhibits soluble adenylyl cyclase (sAC) via a unique allosteric mechanism[1]. LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition[1]. LRE1 (0.5-100 μM) inhibits sperm and mitochondrial functions of sAC[1].
References

[1]. Ramos-Espiritu L, et al. Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat Chem Biol. 2016 Oct;12(10):838-44.

Molecular Formula C12H13ClN4S
Molecular Weight 280.78
Storage condition 2-8℃