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1616413-96-7

1616413-96-7 structure
1616413-96-7 structure
  • Name: UCB9608
  • Chemical Name: UCB9608
  • CAS Number: 1616413-96-7
  • Molecular Formula: C20H26N8O2
  • Molecular Weight: 410.47
  • Catalog: Signaling Pathways PI3K/Akt/mTOR PI4K
  • Create Date: 2019-03-03 20:24:01
  • Modify Date: 2024-01-28 21:39:07
  • UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent[1].

Name UCB9608
Description UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent[1].
Related Catalog
In Vitro UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM. UCB9608 is selective for PI4KIIIβ over PI3KC2 α, β, and γ lipid kinases[1]. UCB9608 inhibits human mixed lymphocyte reaction, the IC50 is 37 nM[1].
References

[1]. Reuberson J, et al. Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. J Med Chem. 2018 Aug 9;61(15):6705-6723.

Molecular Formula C20H26N8O2
Molecular Weight 410.47
Storage condition 2-8℃