1846570-40-8

1846570-40-8 structure

Name: CM-579
Chemical Name: CM-579
CAS Number: 1846570-40-8
Molecular Formula: C₂₉H₄₀N₄O₃
Molecular Weight: 492.65
Catalog: Signaling Pathways Epigenetics DNA Methyltransferase
Create Date: 2019-03-30 13:09:34
Modify Date: 2024-01-30 19:02:25
CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].

Name	CM-579

Description	CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase Signaling Pathways >> Epigenetics >> DNA Methyltransferase
Target	DNA Methyltransferase:32 nM (IC50) DNMT1:1.5 nM (Kd) DNMT3A:92 nM (IC50) DNMT3B:1000 nM (IC50) G9a:16 nM (IC50)
In Vitro	The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1].
References	[1]. San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.