1643120-60-8
1643120-60-8 structure
- Name: YZ129(YZ-129
- Chemical Name: YZ129
- CAS Number: 1643120-60-8
- Molecular Formula: C19H12N2O2
- Molecular Weight: 300.31
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
- Create Date: 2019-03-30 16:12:34
- Modify Date: 2025-08-27 18:45:30
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YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].
| Name | YZ129 |
|---|
| Description | YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1]. |
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| Related Catalog | |
| Target |
HSP90 |
| References |
| Molecular Formula | C19H12N2O2 |
|---|---|
| Molecular Weight | 300.31 |