YZ129(YZ-129

Modify Date: 2024-04-03 12:32:48

YZ129(YZ-129 structure	Common Name	YZ129(YZ-129
	CAS Number	1643120-60-8	Molecular Weight	300.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₂N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of YZ129(YZ-129

YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].

Name	YZ129

Description	YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90
References	[1]. Liu Z, et al. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8.

Molecular Formula	C₁₉H₁₂N₂O₂
Molecular Weight	300.31

DC Chemicals Limited
China
Product Name: YZ129(YZ-129;YZ 129)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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