331467-03-9

331467-03-9 structure

Name: 5-Iodo-indirubin-3'-monoxime
Chemical Name: 5-Iodo-indirubin-3'-monoxime
CAS Number: 331467-03-9
Molecular Formula: C₁₆H₁₀IN₃O₂
Molecular Weight: 403.17
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2019-06-12 13:45:25
Modify Date: 2024-01-30 15:53:48
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].

Name	5-Iodo-indirubin-3'-monoxime

Description	5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3β:9 nM (IC50) Cdk5/p25:20 nM (IC50) Cdk1/cyclin B:25 nM (IC50)
References	[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

Molecular Formula	C₁₆H₁₀IN₃O₂
Molecular Weight	403.17