1295353-98-8

1295353-98-8 structure

Name: Apraglutide
Chemical Name: Apraglutide
CAS Number: 1295353-98-8
Molecular Formula: C₁₇₂H₂₆₃N₄₃O₅₂
Molecular Weight: 3765.25
Catalog: Research Areas Metabolic Disease
Create Date: 2019-08-07 18:39:01
Modify Date: 2025-08-25 13:06:36
Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum[1].

Name	Apraglutide

Description	Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vivo	Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7[1]. Animal Model: NewbornDuroc piglets, 2–5 days old and weighing between 2-2.6 kg[1]. Dosage: 5 mg/kg/dose. Administration: Subcutaneously, twice on days 0 and 4 postsurgery. Result: On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth.
References	[1]. Slim GM, et al. Novel Long-Acting GLP-2 Analogue, FE 203799 (Apraglutide), Enhances Adaptation and Linear Intestinal Growth in a Neonatal Piglet Model of Short Bowel Syndrome with Total Resection of the Ileum. JPEN J Parenter Enteral Nutr. 2019 Jan 6.

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