1622849-43-7
1622849-43-7 structure
- Name: RIPK1 inhibitor GS3145095
- Chemical Name: GSK3145095
- CAS Number: 1622849-43-7
- Molecular Formula: C20H17F2N5O2
- Molecular Weight: 397.38
- Catalog: Signaling Pathways Apoptosis RIP kinase
- Create Date: 2019-06-02 10:54:56
- Modify Date: 2025-08-25 23:45:54
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GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].
| Name | GSK3145095 |
|---|
| Description | GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6.3 nM (RIP1 kinase )[1] |
| In Vitro | GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) [1]. |
| References |
| Molecular Formula | C20H17F2N5O2 |
|---|---|
| Molecular Weight | 397.38 |