200134-22-1

200134-22-1 structure

Name: INH14
Chemical Name: INH14
CAS Number: 200134-22-1
Molecular Formula: C₁₅H₁₆N₂O
Molecular Weight: 240.30
Catalog: Signaling Pathways NF-κB IKK
Create Date: 2019-06-01 21:16:29
Modify Date: 2025-09-25 15:16:20
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1].

Name	INH14

Description	INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	IKKβ:3.59 μM (IC50) IKKα:8.97 μM (IC50)
In Vivo	INH14 (5 µg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice[1]. Animal Model: 8-week old, male, pathogen-free C57BL/6J mice[1] Dosage: 5 µg/g, one hour before Pam2CSK4 injection Administration: I.P. for 2 hours Result: Decreased TNFα production in mice.
References	[1]. Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717.