2074607-48-8

2074607-48-8 structure

Name: IWP-O1
Chemical Name: IWP-O1
CAS Number: 2074607-48-8
Molecular Formula: C₂₆H₂₀N₆O
Molecular Weight: 432.48
Catalog: Signaling Pathways Stem Cell/Wnt Porcupine
Create Date: 2019-06-01 19:30:06
Modify Date: 2026-07-04 16:08:34
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1].

Name	IWP-O1
Synonyms	1H-1,2,3-Triazole-1-acetamide, 5-phenyl-N-(5-phenyl-2-pyridinyl)-4-(4-pyridinyl) 2-(5-Phenyl-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl)-N-(5-phenylpyridin-2-yl)acetamide IWP-O1 >= (HPLC) IWP-O1, 10 mM in DMSO Wnt,IWP-O-1,Porcupine,IWPO1,inhibit,Inhibitor,IWP-O1,IWP O1 IWO-O1

Description	IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt Signaling Pathways >> Stem Cell/Wnt >> Porcupine
Target	EC50: 80 pM (Porcn)[1].
References	[1]. You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.