2074607-48-8

2074607-48-8 structure

Name: IWP-O1
Chemical Name: IWP-O1
CAS Number: 2074607-48-8
Molecular Formula: C₂₆H₂₀N₆O
Molecular Weight: 432.48
Catalog: Signaling Pathways Stem Cell/Wnt Porcupine
Create Date: 2019-06-01 19:30:06
Modify Date: 2024-01-05 18:09:06
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1].

Name	IWP-O1

Description	IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt Signaling Pathways >> Stem Cell/Wnt >> Porcupine
Target	EC50: 80 pM (Porcn)[1].
References	[1]. You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.