1430723-35-5

1430723-35-5 structure

Name: ODM-203
Chemical Name: ODM-203
CAS Number: 1430723-35-5
Molecular Formula: C₂₆H₂₁F₂N₅O₂S
Molecular Weight: 505.54
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2019-06-01 14:59:56
Modify Date: 2024-04-05 08:06:18
ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. ODM-203 exhibits strong anti-tumor activity and induces anti-tumor immunity[1].

Name	ODM-203

Description	ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. ODM-203 exhibits strong anti-tumor activity and induces anti-tumor immunity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	FGFR1:11 nM (IC50) FGFR2:16 nM (IC50) FGFR3:6 nM (IC50) FGFR4:35 nM (IC50) VEGFR1:26 nM (IC50) VEGFR2:9 nM (IC50) VEGFR3:5 nM (IC50) DDR1:6 nM (IC50) RET:8 nM (IC50) SIK3:23 nM (IC50) PDGFRa:35 nM (IC50) MINK1:41 nM (IC50) MAP4K4:49 nM (IC50)
References	[1]. Holmström TH, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019 Jan;18(1):28-38.

Molecular Formula	C₂₆H₂₁F₂N₅O₂S
Molecular Weight	505.54