2252247-80-4

2252247-80-4 structure

Name: SHIP2-IN-1
Chemical Name: SHIP2-IN-1
CAS Number: 2252247-80-4
Molecular Formula: C₁₇H₁₃Cl₂FN₄O
Molecular Weight: 379.22
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2019-06-01 22:09:45
Modify Date: 2024-01-12 16:49:11
SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].

Name	SHIP2-IN-1

Description	SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Neurological Disease
Target	IC50: 2 µM (SHIP2)[1]
In Vitro	SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells[1].
References	[1]. Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.