SHIP2-IN-1

Modify Date: 2024-01-12 16:49:11

SHIP2-IN-1 structure	Common Name	SHIP2-IN-1
	CAS Number	2252247-80-4	Molecular Weight	379.22
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₃Cl₂FN₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SHIP2-IN-1

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].

Name	SHIP2-IN-1

Description	SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Neurological Disease
Target	IC50: 2 µM (SHIP2)[1]
In Vitro	SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells[1].
References	[1]. Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422.

Molecular Formula	C₁₇H₁₃Cl₂FN₄O
Molecular Weight	379.22
Storage condition	-20°C

DC Chemicals Limited
China
Product Name: SHIP2-IN-1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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