1597426-53-3

1597426-53-3 structure

Name: T-448
Chemical Name: T-448
CAS Number: 1597426-53-3
Molecular Formula: C₂₁H₂₄N₄O₅S
Molecular Weight: 444.5
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2019-06-01 20:46:34
Modify Date: 2026-08-02 20:16:46
T-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1].

Name	T-448

Description	T-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Demethylase Research Areas >> Neurological Disease
Target	IC50: 22 nM (LSD1)[1].
References	[1]. Matsuda S, et al. T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice. Neuropsychopharmacology. 2018 Dec 22.