117609-50-4

117609-50-4 structure

Name: Tauroursodeoxycholate dihydrate
Chemical Name: Tauroursodeoxycholate dihydrate
CAS Number: 117609-50-4
Molecular Formula: C₂₆H₄₉NO₈S
Molecular Weight: 535.73
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2019-06-01 17:38:59
Modify Date: 2024-01-11 10:53:11
Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2].

Name	Tauroursodeoxycholate dihydrate

Description	Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK[1] Caspase-3, Caspase-12[2]
References	[1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16. [2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345.