Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GLPG2451
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

2055015-61-5

2055015-61-5 structure

2055015-61-5 structure

Name: GLPG2451
Chemical Name: GLPG2451
CAS Number: 2055015-61-5
Molecular Formula: C₁₆H₁₆F₃N₃O₅S
Molecular Weight: 419.38
Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
Create Date: 2019-07-01 01:26:15
Modify Date: 2024-01-02 15:54:09
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1].

Name	GLPG2451

Description	GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Inflammation/Immunology
Target	Cystic fibrosis transmembrane conductance regulator[1]
In Vitro	GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells[1].
References	[1]. Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221.

Molecular Formula	C₁₆H₁₆F₃N₃O₅S
Molecular Weight	419.38