2300982-44-7

2300982-44-7 structure

Name: RIPK1-IN-7
Chemical Name: RIPK1-IN-7
CAS Number: 2300982-44-7
Molecular Formula: C₂₅H₂₂F₃N₅O₂
Molecular Weight: 481.47
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2019-06-29 22:01:05
Modify Date: 2024-02-01 23:40:37
RIPK1-IN-7 is a potent and selective receptor-interacting protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model[1].

Name	RIPK1-IN-7

Description	RIPK1-IN-7 is a potent and selective receptor-interacting protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> RIP kinase
Target	Kd: 4 nM (Receptor-interacting protein kinase 1)[1] IC50: 11 nM (Receptor-interacting protein kinase 1)[1]
In Vitro	RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC50 of 2nM[1]. RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively[1].
References	[1]. Li Y, et al. Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. J Med Chem. 2018 Dec 27;61(24):11398-11414.