1283125-73-4

1283125-73-4 structure

Name: β3-AR agonist 1
Chemical Name: β3-AR agonist 1
CAS Number: 1283125-73-4
Molecular Formula: C₂₂H₂₈N₄O₄S
Molecular Weight: 444.55
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2019-08-04 12:28:58
Modify Date: 2024-01-09 13:13:52
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1].

Name	β3-AR agonist 1

Description	β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	EC50: 18 nM (β3-AR)[1]
In Vivo	β3-AR agonist 1 (compound 15) shows dose-dependent β3-AR-mediated responses in marmoset urinary bladder smooth muscle, has a desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats[1].
References	[1]. Wada Y, et al. Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects. J Med Chem. 2017 Apr 27;60(8):3252-3265.

Molecular Formula	C₂₂H₂₈N₄O₄S
Molecular Weight	444.55