β3-AR agonist 1
Modify Date: 2024-01-09 13:13:52
β3-AR agonist 1 structure
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Common Name | β3-AR agonist 1 | ||
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| CAS Number | 1283125-73-4 | Molecular Weight | 444.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H28N4O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of β3-AR agonist 1β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1]. |
| Name | β3-AR agonist 1 |
|---|
| Description | β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1]. |
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| Related Catalog | |
| Target |
EC50: 18 nM (β3-AR)[1] |
| In Vivo | β3-AR agonist 1 (compound 15) shows dose-dependent β3-AR-mediated responses in marmoset urinary bladder smooth muscle, has a desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats[1]. |
| References |
| Molecular Formula | C22H28N4O4S |
|---|---|
| Molecular Weight | 444.55 |