1818291-27-8

1818291-27-8 structure

Name: BI-0252
Chemical Name: BI-0252
CAS Number: 1818291-27-8
Molecular Formula: C₃₀H₂₆Cl₂FN₃O₃
Molecular Weight: 566.45
Catalog: Signaling Pathways Apoptosis MDM-2/p53
Create Date: 2019-08-04 09:02:58
Modify Date: 2024-01-16 18:11:55
BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1].

Name	BI-0252

Description	BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
Target	IC50: 4 nM (MDM2-p53)[1]
References	[1]. Gollner A, et al. Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction. J Med Chem. 2016 Nov 23;59(22):10147-10162.

Molecular Formula	C₃₀H₂₆Cl₂FN₃O₃
Molecular Weight	566.45