BI-0252

Modify Date: 2025-08-26 16:43:00

BI-0252 Structure
BI-0252 structure
 Common Name BI-0252
CAS Number 1818291-27-8 Molecular Weight 566.45
Density N/A Boiling Point N/A
Molecular Formula C30H26Cl2FN3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BI-0252


BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1].

 Names

Name BI-0252

 BI-0252 Biological Activity

Description BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1].
Related Catalog
Target

IC50: 4 nM (MDM2-p53)[1]

References

[1]. Gollner A, et al. Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction. J Med Chem. 2016 Nov 23;59(22):10147-10162.

 Chemical & Physical Properties

Molecular Formula C30H26Cl2FN3O3
Molecular Weight 566.45
InChIKey CCPUFNJKOGKOOG-MHODHZNISA-N
SMILES O=C(O)c1ccc(C2CC3C(N2)C(c2cccc(Cl)c2F)C2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
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Chemsrc provides BI-0252(CAS#:1818291-27-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BI-0252 are included as well.>> amp version: BI-0252

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