BI-0252

Modify Date: 2024-01-16 18:11:55

BI-0252 structure	Common Name	BI-0252
	CAS Number	1818291-27-8	Molecular Weight	566.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₂₆Cl₂FN₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BI-0252

BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1].

Name	BI-0252

Description	BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
Target	IC50: 4 nM (MDM2-p53)[1]
References	[1]. Gollner A, et al. Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction. J Med Chem. 2016 Nov 23;59(22):10147-10162.

Molecular Formula	C₃₀H₂₆Cl₂FN₃O₃
Molecular Weight	566.45

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BI-0252
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: BI-0252
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: BI-0252
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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BI-0252

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BI-0252 Biological Activity

Chemical & Physical Properties