1622262-55-8

1622262-55-8 structure

Name: BRCA1-IN-2
Chemical Name: BRCA1-IN-2
CAS Number: 1622262-55-8
Molecular Formula: C₂₆H₃₃N₄O₇P
Molecular Weight: 544.54
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2019-08-03 18:41:58
Modify Date: 2024-01-09 10:04:22
BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions[1].

Name	BRCA1-IN-2

Description	BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	IC50: 0.31 μM (BRCA1)[1] Kd: 0.3 μM (BRCA1)[1]
References	[1]. Na Z, et al. Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays. Methods Mol Biol. 2017;1518:139-156.

Molecular Formula	C₂₆H₃₃N₄O₇P
Molecular Weight	544.54