2092921-50-9

2092921-50-9 structure

Name: Glutaminyl Cyclase Inhibitor 3
Chemical Name: Glutaminyl Cyclase Inhibitor 3
CAS Number: 2092921-50-9
Molecular Formula: C₂₄H₃₂N₆O₂S
Molecular Weight: 468.61
Catalog: Research Areas Neurological Disease
Create Date: 2019-08-04 12:24:58
Modify Date: 2024-01-09 17:21:29
Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1].

Name	Glutaminyl Cyclase Inhibitor 3

Description	Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1].
Related Catalog	Research Areas >> Neurological Disease
Target	IC50: 4.5 nM (hGC)[1].
References	[1]. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590.

Molecular Formula	C₂₄H₃₂N₆O₂S
Molecular Weight	468.61