353484-30-7

353484-30-7 structure

Name: LDN-0088050
Chemical Name: LDN-0088050
CAS Number: 353484-30-7
Molecular Formula: C₁₉H₁₈BrNO₂
Molecular Weight: 372.26
Catalog: Signaling Pathways Metabolic Enzyme/Protease FABP
Create Date: 2019-08-03 16:34:58
Modify Date: 2024-01-10 15:12:17
LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1].

Name	LDN-0088050

Description	LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> FABP
Target	Ki: 0.29 μM (FABP4), 1.3 μM (FABP3)[1] Kd: 2.05 μM (FABP4)[1]
In Vitro	LDN 0088050 significantly inhibits LPS-induced expression of both TNFα and IL-6 in RAW264.7 cells[1].
References	[1]. Zhou Y, et al. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. Bioorg Med Chem. 2016 Sep 15;24(18):4310-4317.

Molecular Formula	C₁₉H₁₈BrNO₂
Molecular Weight	372.26