2231744-29-7

2231744-29-7 structure

Name: MT-802
Chemical Name: MT-802
CAS Number: 2231744-29-7
Molecular Formula: C₄₁H₄₁N₉O₈
Molecular Weight: 787.82
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2019-08-04 08:04:59
Modify Date: 2024-01-13 19:42:30
MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1].

Name	MT-802

Description	MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Signaling Pathways >> PROTAC >> PROTAC
Target	DC50: 1 nM (BTK)[1].
In Vitro	MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1].
References	[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.