MT-802

Modify Date: 2024-01-13 19:42:30

MT-802 Structure
MT-802 structure
Common Name MT-802
CAS Number 2231744-29-7 Molecular Weight 787.82
Density N/A Boiling Point N/A
Molecular Formula C41H41N9O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MT-802


MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1].

 Names

Name MT-802

 MT-802 Biological Activity

Description MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1].
Related Catalog
Target

DC50: 1 nM (BTK)[1].

In Vitro MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1].
References

[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.

 Chemical & Physical Properties

Molecular Formula C41H41N9O8
Molecular Weight 787.82
Storage condition -20°C
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