192581-24-1

192581-24-1 structure

Name: BIIL-260 hydrochloride
Chemical Name: BIIL-260 hydrochloride
CAS Number: 192581-24-1
Molecular Formula: C₃₀H₃₁ClN₂O₃
Molecular Weight: 503.03
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2019-09-07 10:20:18
Modify Date: 2024-01-03 18:18:55
BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1].

Name	BIIL-260 hydrochloride

Description	BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	Ki: 1.7 nM (LTB4 receptor)[1]
In Vitro	BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM
References	[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.

Molecular Formula	C₃₀H₃₁ClN₂O₃
Molecular Weight	503.03