BIIL-260 hydrochloride

Modify Date: 2024-01-03 18:18:55

BIIL-260 hydrochloride Structure
BIIL-260 hydrochloride structure
 Common Name BIIL-260 hydrochloride
CAS Number 192581-24-1 Molecular Weight 503.03
Density N/A Boiling Point N/A
Molecular Formula C30H31ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BIIL-260 hydrochloride


BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1].

 Names

Name BIIL-260 hydrochloride

 BIIL-260 hydrochloride Biological Activity

Description BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1].
Related Catalog
Target

Ki: 1.7 nM (LTB4 receptor)[1]

In Vitro BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM
References

[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.

 Chemical & Physical Properties

Molecular Formula C30H31ClN2O3
Molecular Weight 503.03
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