2102494-14-2

2102494-14-2 structure

Name: OP-3633
Chemical Name: OP-3633
CAS Number: 2102494-14-2
Molecular Formula: C₃₀H₃₉NO₂
Molecular Weight: 445.64
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2019-09-07 12:38:18
Modify Date: 2024-01-09 19:51:34
OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].

Name	OP-3633

Description	OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
Target	IC50: 29 nM (GR)[1]
In Vitro	OP-3633 exhibits low progesterone receptor (PR) agonism with an EC50 higher than 2500 nM[1]. OP-3633 exhibits low androgen receptor (PR) antagonism, with an IC50 of 1135 nM[1].
References	[1]. Du X, et al. Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633). J Med Chem. 2019 Jul 25;62(14):6751-6764.

Molecular Formula	C₃₀H₃₉NO₂
Molecular Weight	445.64