1619971-30-0

1619971-30-0 structure

Name: Autotaxin inhibitor compound 1
Chemical Name: Autotaxin-IN-1
CAS Number: 1619971-30-0
Molecular Formula: C₂₁H₂₃N₇O₂
Molecular Weight: 405.45
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2019-10-07 08:25:33
Modify Date: 2024-01-13 19:56:47
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain[1].

Name	Autotaxin-IN-1

Description	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	Autotaxin:2 nM (IC50)
In Vivo	Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours[1]. Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM•h[1]. Animal Model: Normal rat[1] Dosage: 1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study) Administration: I.v. (1.0 mg/kg); p.o. (10 mg/kg) Result: Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg). Has Cmax of 660 nM and AUC of 3440 nM▪h (p.o.; 10 mg/kg).
References	[1]. Jones SB, et al. Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design. ACS Med Chem Lett. 2016 Aug 2;7(9):857-61.