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2042347-69-1

2042347-69-1 structure
2042347-69-1 structure
  • Name: AZD9898
  • Chemical Name: AZD9898
  • CAS Number: 2042347-69-1
  • Molecular Formula: C20H19ClF3N3O4
  • Molecular Weight: 457.83
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Gutathione S-transferase
  • Create Date: 2019-10-13 17:54:56
  • Modify Date: 2025-08-27 17:03:43
  • AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1].

Name AZD9898
Description AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1].
Related Catalog
Target

IC50: 0.28 nM (LTC4S)[1].

In Vivo AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised[1]. Animal Model: Rat 6M/group[1]. Dosage: 10 and 100 mg/kg (for Toxicology Study). Administration: Sing oral dose. Result: Showed no signs of testicular toxicity, and only adaptive changes in the liver due to cytochrome P450 induction which were not judged adverse, providing a 200 fold margin between the no adverse effect level and the predicted human exposure at the predicted therapeutic dose.
References

[1]. Munck Af Rosenschöld M, et al. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. J Med Chem. 2019 Aug 30.

Molecular Formula C20H19ClF3N3O4
Molecular Weight 457.83
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