1241902-40-8

1241902-40-8 structure

Name: GNE-0439
Chemical Name: GNE-0439
CAS Number: 1241902-40-8
Molecular Formula: C₂₁H₃₁NO₃
Molecular Weight: 345.48
Catalog: Research Areas Others
Create Date: 2019-10-09 10:55:29
Modify Date: 2024-01-10 18:11:50
GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].

Name	GNE-0439

Description	GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	IC50: 0.34 uM (Nav1.7)[1]
References	[1]. Chernov-Rogan T, et al. Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801.

Molecular Formula	C₂₁H₃₁NO₃
Molecular Weight	345.48

Hazard Codes	Xi