GNE-0439
Modify Date: 2024-01-10 18:11:50
GNE-0439 structure
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Common Name | GNE-0439 | ||
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| CAS Number | 1241902-40-8 | Molecular Weight | 345.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H31NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNE-0439GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1]. |
| Name | GNE-0439 |
|---|
| Description | GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1]. |
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| Related Catalog | |
| Target |
IC50: 0.34 uM (Nav1.7)[1] |
| References |
| Molecular Formula | C21H31NO3 |
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| Molecular Weight | 345.48 |
| Hazard Codes | Xi |
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