881487-77-0

881487-77-0 structure

Name: KPT-6566
Chemical Name: KPT-6566
CAS Number: 881487-77-0
Molecular Formula: C₂₂H₂₁NO₅S₂
Molecular Weight: 443.54
Catalog: Research Areas Cancer
Create Date: 2019-10-07 22:24:52
Modify Date: 2024-01-08 02:21:14
KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity[1].

Name	KPT-6566

Description	KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 640 nM (PIN1 PPIase)[1] Ki: 625.2 nM (PIN1 PPIase)[1]
References	[1]. Campaner E, et al. A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action. Nat Commun. 2017 Jun 9;8:15772.

Molecular Formula	C₂₂H₂₁NO₅S₂
Molecular Weight	443.54