881487-77-0
881487-77-0 structure
- Name: KPT-6566
- Chemical Name: KPT-6566
- CAS Number: 881487-77-0
- Molecular Formula: C22H21NO5S2
- Molecular Weight: 443.54
- Catalog: Research Areas Cancer
- Create Date: 2019-10-07 22:24:52
- Modify Date: 2025-08-22 23:44:54
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KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity[1].
| Name | KPT-6566 |
|---|
| Description | KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity[1]. |
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| Related Catalog | |
| Target |
IC50: 640 nM (PIN1 PPIase)[1] Ki: 625.2 nM (PIN1 PPIase)[1] |
| References |
| Molecular Formula | C22H21NO5S2 |
|---|---|
| Molecular Weight | 443.54 |