2163793-38-0

2163793-38-0 structure

Name: PROTAC Mcl1 degrader-1
Chemical Name: Mcl1-IN-14
CAS Number: 2163793-38-0
Molecular Formula: C₄₅H₄₅BrN₆O₈S
Molecular Weight: 909.84
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2019-10-07 11:08:42
Modify Date: 2024-01-13 11:37:30
Mcl1-IN-14 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. Mcl1-IN-14 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity[1].

Name	Mcl1-IN-14

Description	Mcl1-IN-14 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. Mcl1-IN-14 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	Mcl-1:0.78 μM (IC50)
References	[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.