1481641-08-0

1481641-08-0 structure

Name: RIPK1-IN-4
Chemical Name: RIPK1-IN-4
CAS Number: 1481641-08-0
Molecular Formula: C₂₃H₂₃N₅O₂
Molecular Weight: 401.46
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2019-10-07 19:18:52
Modify Date: 2024-02-05 19:12:16
RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].

Name	RIPK1-IN-4

Description	RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Inflammation/Immunology
Target	IC50: 16 nM (RIP1) and 10 nM (ADP-Glo)[1]
References	[1]. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43.

Molecular Formula	C₂₃H₂₃N₅O₂
Molecular Weight	401.46