1673568-73-4
1673568-73-4 structure
- Name: KAR-5417
- Chemical Name: Rodatristat
- CAS Number: 1673568-73-4
- Molecular Formula: C27H27ClF3N5O3
- Molecular Weight: 561.98
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Tryptophan Hydroxylase
- Create Date: 2019-10-07 18:40:52
- Modify Date: 2024-01-08 17:29:47
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Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) inhibitor with an IC50 value of 33 nM, and shows robust reduction of intestinal serotonin (5-HT) levels in mice. Rodatristat also shows potent inhibition of TPH2 (IC50 of 7 nM)[1].
| Name | Rodatristat |
|---|
| Description | Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) inhibitor with an IC50 value of 33 nM, and shows robust reduction of intestinal serotonin (5-HT) levels in mice. Rodatristat also shows potent inhibition of TPH2 (IC50 of 7 nM)[1]. |
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| Related Catalog | |
| In Vivo | Rodatristat (10 mg/kg and 50 mg/kg; oral administration; mice) treatment decreases intestinal 5-HT concentrations at 50 mg/kg, their efficacy drop off significantly at the lower 10 mg/kg dose[1]. Animal Model: Mice[1] Dosage: 10 mg/kg and 50 mg/kg Administration: Oral administration Result: Decreased intestinal 5-HT concentrations at 50 mg/kg, their efficacy dropped off significantly at the lower 10 mg/kg dose. |
| References |
| Molecular Formula | C27H27ClF3N5O3 |
|---|---|
| Molecular Weight | 561.98 |