781628-99-7

781628-99-7 structure

Name: SBI-477
Chemical Name: SBI-477
CAS Number: 781628-99-7
Molecular Formula: C₂₄H₂₅N₃O₆S
Molecular Weight: 483.54
Catalog: Research Areas Metabolic Disease
Create Date: 2019-10-09 17:44:29
Modify Date: 2024-01-11 19:14:19
SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain–containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].

Name	SBI-477

Description	SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain–containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	MondoA[1]
References	[1]. Ahn B, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-79.

Molecular Formula	C₂₄H₂₅N₃O₆S
Molecular Weight	483.54