1913291-02-7

1913291-02-7 structure

Name: WRG-28
Chemical Name: WRG-28
CAS Number: 1913291-02-7
Molecular Formula: C₂₁H₁₈N₂O₅S
Molecular Weight: 410.44
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Discoidin Domain Receptor
Create Date: 2019-10-07 22:38:52
Modify Date: 2025-08-24 20:44:23
WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].

Name	WRG-28

Description	WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Discoidin Domain Receptor
Target	DDR2:230 nM (IC50)
References	[1]. Grither WR, et al. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794.

Molecular Formula	C₂₁H₁₈N₂O₅S
Molecular Weight	410.44

Hazard Codes	Xi