WRG-28

Modify Date: 2024-04-03 13:37:12

WRG-28 structure	Common Name	WRG-28
	CAS Number	1913291-02-7	Molecular Weight	410.44
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₈N₂O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of WRG-28

WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].

Name	WRG-28

Description	WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Discoidin Domain Receptor
Target	DDR2:230 nM (IC50)
References	[1]. Grither WR, et al. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794.

Molecular Formula	C₂₁H₁₈N₂O₅S
Molecular Weight	410.44

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: WRG-28
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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