WRG-28

Modify Date: 2025-08-24 20:44:23

WRG-28 Structure
WRG-28 structure
Common Name WRG-28
CAS Number 1913291-02-7 Molecular Weight 410.44
Density N/A Boiling Point N/A
Molecular Formula C21H18N2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WRG-28


WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].

 Names

Name WRG-28

 WRG-28 Biological Activity

Description WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].
Related Catalog
Target

DDR2:230 nM (IC50)

References

[1]. Grither WR, et al. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794.

 Chemical & Physical Properties

Molecular Formula C21H18N2O5S
Molecular Weight 410.44

 Safety Information

Hazard Codes Xi
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here



Get all suppliers and price by the below link:

WRG-28 suppliers

WRG-28 price

Related Compounds: More...
sodium,3-[2-[[3-carbamoyloxy-2-[[2-(2,3-dihydroxypropanoylamino)acetyl]-methylamino]propanoyl]amino]propanoylamino]-2-oxoazetidine-1-sulfonate
88273-26-1
(24ξ)-28-[[2-O-(2-O,4-O-Dimethyl-β-D-xylopyranosyl)-α-L-arabinofuranosyl]oxy]-5α-ergostane-3β,4β,6α,8,15β,16β-hexaol
107041-31-6
COR 28 22
84541-62-8
COR 28 11
84541-64-0
18,28-Cyclo-16,28-secosolanid-5-en-3β-ol
468-24-6
(24ξ)-28-[[2-O-(2-O,4-O-Dimethyl-β-D-xylopyranosyl)-α-L-arabinofuranosyl]oxy]-5α-ergostane-3β,6α,8,15β,16β-pentaol
107041-32-7
16,28-Secosolanida-5,22(28)-diene-3β,16α-diol
29271-49-6
Somatostatin-28 trifluoroacetate salt
73032-94-7
(24ξ)-28-[(5-O-Methyl-β-D-galactofuranosyl)oxy]-5α-ergostane-3β,6α,7α,8,15β,24-hexaol
109575-71-5
N-(2-(4-methylpiperazin-1-yl)-2-(thiophen-3-yl)ethyl)-[1,1'-biphenyl]-4-sulfonamide
946304-45-6
3,4-dimethoxy-N-(2-(pyrrolidin-1-yl)-2-(thiophen-3-yl)ethyl)benzenesulfonamide
946304-48-9
2-phenyl-N-(2-(pyrrolidin-1-yl)-2-(thiophen-3-yl)ethyl)ethanesulfonamide
946357-01-3
4-methoxy-3,5-dimethyl-N-(2-(pyrrolidin-1-yl)-2-(thiophen-3-yl)ethyl)benzenesulfonamide
946357-04-6
(1-Cyanoindolizin-2-yl)methyl 2-chloropyridine-3-carboxylate
938923-04-7
4-methoxy-2-methyl-N-(2-(pyrrolidin-1-yl)-2-(thiophen-3-yl)ethyl)benzenesulfonamide
955238-05-8
Benzenesulfonamide,3-[[5-(3-bromophenyl)-2-oxazolyl]amino]-4-methoxy-
681002-81-3
Benzenesulfonamide,3-[[5-(4-fluorophenyl)-2-oxazolyl]amino]-4-methoxy-
681002-78-8
Benzenesulfonamide,3-[[5-(4-fluorophenyl)-2-oxazolyl]amino]-4-methoxy-n-(3-methoxypropyl)-
681003-18-9
Benzenesulfonamide,3-[[5-(4-fluorophenyl)-2-oxazolyl]amino]-4-methoxy-n-methyl-
681003-19-0