1611483-29-4

1611483-29-4 structure

Name: (E)-GABAB receptor antagonist 1
Chemical Name: (E)-GABAB receptor antagonist 1
CAS Number: 1611483-29-4
Molecular Formula: C₁₈H₂₄O₄
Molecular Weight: 304.38
Create Date: 2019-12-07 19:13:54
Modify Date: 2024-01-23 15:31:35
(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM[1].

Name	(E)-GABAB receptor antagonist 1

Description	(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM[1].
Target	GABAB receptor[1]
In Vitro	(E)-GABAB receptor antagonist 1 (compound 14) decreases agonist GABA-induced maximal effect of IP3 production in HEK293 cells overexpressing GABAB receptors and Gqi9 proteins without changing the EC50[1].
References	[1]. Chen LH, et al. Discovery of a Negative Allosteric Modulator of GABAB Receptors. ACS Med Chem Lett. 2014 May 27;5(7):742-7.

Molecular Formula	C₁₈H₂₄O₄
Molecular Weight	304.38