1443290-89-8
1443290-89-8 structure
- Name: ML 67-33
- Chemical Name: ML67-33
- CAS Number: 1443290-89-8
- Molecular Formula: C18H17Cl2N5
- Molecular Weight: 374.27
- Create Date: 2019-12-07 13:48:54
- Modify Date: 2024-09-14 11:08:25
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ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].
| Name | ML67-33 |
|---|
| Description | ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1]. |
|---|---|
| Target |
EC50: 36.3 μM (K2P2.1 (TREK-1)), 9.7 μM (K2P2.1 (TREK-1), in HEK293 cells)[1]. |
| In Vitro | ML67-33 activates K2P channels and mutants with EC50s of 21.8±1.3 μM, 49.4±1.1 μM, 30.2±1.4 μM, and 27.3±1.2 μM for K2P2.1 (TREK-1) W275S, K2P2.1 (TREK-1)-3G, K2P10.1 (TREK-2), K2P4.1 (TRAAK), respectively[1]. |
| References |
| Molecular Formula | C18H17Cl2N5 |
|---|---|
| Molecular Weight | 374.27 |