2247894-32-0

2247894-32-0 structure

Name: SGC AAK1 1
Chemical Name: SGC-AAK1-1
CAS Number: 2247894-32-0
Molecular Formula: C₂₁H₂₅N₅O₃S
Molecular Weight: 427.52
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2019-12-08 09:08:54
Modify Date: 2024-04-01 14:05:27
SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1].

Name	SGC-AAK1-1

Description	SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Others
Target	IC50: 270 nM (AAK1)[1]. Ki: 9 nM (AAK1)[1]
In Vitro	SGC-AAK1-1 (1.25 μM) significantly reduces phosphorylation of AP2M1 (T156) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells[1]. SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription[1].
References	[1]. Agajanian MJ, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019 Jan 2;26(1):79-93.e8.

Molecular Formula	C₂₁H₂₅N₅O₃S
Molecular Weight	427.52