Name | WYE-687 dihydrochloride |
---|
Description | WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1]. |
---|---|
Related Catalog | |
Target |
mTOR:7 nM (IC50) mTORC1 mTORC2 PI3K alpha:81 nM (IC50) PI3K gamma:3.11 μM (IC50) CK1 gamma1:17.8 μM (IC50) p38 alpha:28.9 μM (IC50) |
References |
Molecular Formula | C28H34Cl2N8O3 |
---|---|
Molecular Weight | 601.53 |
Hazard Codes | Xi |
---|