WYE 687 dihydrochloride

Modify Date: 2024-01-12 18:43:19

WYE 687 dihydrochloride structure	Common Name	WYE 687 dihydrochloride
	CAS Number	1702364-87-1	Molecular Weight	601.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₃₄Cl₂N₈O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of WYE 687 dihydrochloride

WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].

Name	WYE-687 dihydrochloride

Description	WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	mTOR:7 nM (IC50) mTORC1 mTORC2 PI3K alpha:81 nM (IC50) PI3K gamma:3.11 μM (IC50) CK1 gamma1:17.8 μM (IC50) p38 alpha:28.9 μM (IC50)
References	[1]. Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40. [2]. Cheng F, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330.

Molecular Formula	C₂₈H₃₄Cl₂N₈O₃
Molecular Weight	601.53

Hazard Codes	Xi

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WYE 687 dihydrochloride

Use of WYE 687 dihydrochloride

Names

WYE 687 dihydrochloride Biological Activity

Chemical & Physical Properties

Safety Information

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.